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NUP50 (16D10)Mouse Monoclonal Antibody(ascites)

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产品基本信息

产品货号
BD-PB0694
产品名称
NUP50 (16D10)Mouse Monoclonal Antibody(ascites)
别名
Nuclear pore complex protein Nup50, 50 kDa nucleoporin, Nuclear pore-associated protein 60 kDa-like, Nucleoporin Nup50, NUP50, NPAP60L
类别
常规抗体
推荐应用
WB
反应种属
Human
Human Gene ID
NP_009103.2;NP_705931.1
Human Swissprot No.
Q9UKX7
特异性
This NUP50 monoclonal antibody is generated from mouse immunized with NUP50 recombinant protein.
稀释度
WB~~1:1000~3200
预测分子量
50kDa
同种型
IgG1,k
背景介绍
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.
组织表达
Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver
细胞定位
Nucleus, nuclear pore complex. Nucleus membrane {ECO:0000250|UniProtKB:O08587}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08587}; Nucleoplasmic side {ECO:0000250|UniProtKB:O08587}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis (PubMed:12802065) Associates with the newly formed nuclear membrane during telophase (PubMed:12802065). In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (By similarity). {ECO:0000250|UniProtKB:O08587, ECO:0000269|PubMed:12802065}
期货
现货
纯化
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

NUP50 western blot analysis in Jurkat cell line lysates (35μg/lane).This demonstrates the NUP50 antibody detected the NUP50 protein (arrow).

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