产品名称
NUP50 (16D10)Mouse Monoclonal Antibody(ascites)
别名
Nuclear pore complex protein Nup50, 50 kDa nucleoporin, Nuclear pore-associated protein 60 kDa-like, Nucleoporin Nup50, NUP50, NPAP60L
Human Gene ID
NP_009103.2;NP_705931.1
Human Swissprot No.
Q9UKX7
特异性
This NUP50 monoclonal antibody is generated from mouse immunized with NUP50 recombinant protein.
背景介绍
The nuclear pore complex is a massive structure that
extends across the nuclear envelope, forming a gateway that
regulates the flow of macromolecules between the nucleus and the
cytoplasm. Nucleoporins are the main components of the nuclear pore
complex in eukaryotic cells. The protein encoded by this gene is a
member of the FG-repeat containing nucleoporins that functions as a
soluble cofactor in importin-alpha:beta-mediated nuclear protein
import. Pseudogenes of this gene are found on chromosomes 5, 6, and
14. Two transcript variants encoding different isoforms have been
found for this gene.
组织表达
Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver
细胞定位
Nucleus, nuclear pore complex. Nucleus membrane {ECO:0000250|UniProtKB:O08587}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08587}; Nucleoplasmic side {ECO:0000250|UniProtKB:O08587}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis (PubMed:12802065) Associates with the newly formed nuclear membrane during telophase (PubMed:12802065). In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (By similarity). {ECO:0000250|UniProtKB:O08587, ECO:0000269|PubMed:12802065}
纯化
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.