产品名称
RABX5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27342
Human Swissprot No.
Q9UJ41
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UJ41/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56715
Mouse Swissprot No.
Q9JM13
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JM13
免疫原
Synthesized peptide derived from human RABX5 AA range: 291-341
特异性
This antibody detects endogenous levels of RABX5 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010],
细胞定位
Cytoplasm . Early endosome . Recycling endosome .
功能
function:Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.,PTM:Monoubiquitinated.,similarity:Contains 1 A20-type zinc finger.,similarity:Contains 1 VPS9 domain.,subunit:Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
