BD-PB0670

BRDT Rabbit Polyclonal Antibody (N-term)

Bromodomain testis-specific protein, Cancer/testis antigen 9, CT9, RING3-like protein, BRDT

常规抗体

WB

Human

NP_001229734.1;NP_001229735.1;NP_001229736.1;NP_001229737.1;NP_001229739.1;NP_001717.2;NP_997072.1

Q58F21

This BRDT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BRDT.

WB~~1:2000

108kDa

Rabbit Ig

BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Two transcript variants encoding the same protein have been found for this gene. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder

Nucleus Note=Detected on chromatin. {ECO:0000250|UniProtKB:Q91Y44}

现货

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.