产品名称
KIT Rabbit Polyclonal Antibody (C-term S821/Y823)
别名
Mast/stem cell growth factor receptor Kit, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, CD117, Kit, Sl
Human Swissprot No.
P05532
Mouse Gene ID
NP_001116205.1;NP_066922.2
特异性
This KIT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 807-836 amino acids from the C-terminal region of human KIT.
背景介绍
This gene encodes the human homolog of the proto-oncogene
c-kit. C-kit was first identified as the cellular homolog of the
feline sarcoma viral oncogene v-kit. This protein is a type 3
transmembrane receptor for MGF (mast cell growth factor, also known
as stem cell factor). Mutations in this gene are associated with
gastrointestinal stromal tumors, mast cell disease, acute
myelogenous lukemia, and piebaldism. Multiple transcript variants
encoding different isoforms have been found for this gene.
组织表达
Isoform 1 and isoform 2 are detected in bone marrow cells, spermatogonia and spermatocytes, but not in round spermatids, elongating spermatids and spermatozoa. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa, but not in spermatogonia and spermatocytes (at protein level). Isoform 1 is widely expressed and detected in fetal liver and bone marrow. Isoform 3 is detected in bone marrow cells enriched in hematopoietic stem cells
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
