产品名称
YAP (phospho-Ser109) Rabbit Polyclonal Antibody
别名
Yorkie homolog (65 kDa Yes-associated protein) (YAP65)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10413
Human Swissprot No.
P46937
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P46937/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22601
Mouse Swissprot No.
P46938
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P46938
Rat Gene Link
https://www.uniprot.org/uniprot/363014
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q2EJA0
免疫原
Synthesized phosho peptide around human YAP (Ser109)
特异性
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser109)
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],
组织表达
Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
细胞定位
Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
功能
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
