产品名称
WIPI2 (phospho-Ser413) Rabbit Polyclonal Antibody
别名
WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/26100
Human Swissprot No.
Q9Y4P8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y4P8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/74781
Mouse Swissprot No.
Q80W47
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80W47
Rat Gene Link
https://www.uniprot.org/uniprot/288498
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AY57
免疫原
Synthesized phosho peptide around human WIPI2 (Ser413)
特异性
This antibody detects endogenous levels of Human Mouse Rat WIPI2 (phospho-Ser413)
宿主
Polyclonal, Rabbit,IgG
背景介绍
WD repeat domain, phosphoinositide interacting 2(WIPI2) Homo sapiens WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008],
组织表达
Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.
细胞定位
Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. .
功能
similarity:Contains 3 WD repeats.,tissue specificity:Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
