产品名称
ULK1 (phospho-Ser757) Rabbit Polyclonal Antibody
别名
Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8408
Human Swissprot No.
O75385
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75385/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22241
Mouse Swissprot No.
O70405
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70405
免疫原
Synthesized phosho peptide around human ULK1 (Ser757)
特异性
This antibody detects endogenous levels of Human Mouse Rat ULK1 (phospho-Ser757)
宿主
Polyclonal, Rabbit,IgG
组织表达
Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
细胞定位
Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. .
信号通路
Regulation of autophagy;mTOR;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with GABARAP and GABARAPL2.,tissue specificity:Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
