产品名称
TPOR (phospho-Tyr626) Rabbit Polyclonal Antibody
别名
Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4352
Human Swissprot No.
P40238
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P40238/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17480
Mouse Swissprot No.
Q08351
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q08351
免疫原
Synthesized phosho peptide around human TPOR (Tyr626)
特异性
This antibody detects endogenous levels of Human TPOR (phospho-Tyr626)
宿主
Polyclonal, Rabbit,IgG
背景介绍
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important
组织表达
Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
细胞定位
Cell membrane ; Single-pass type I membrane protein. Golgi apparatus . Cell surface .
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
caution:It is uncertain whether Met-1 or Met-8 is the initiator.,disease:Defects in MPL are a cause of congenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]. CAMT is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with ATXN2L.,tissue specificity:Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
