产品名称
TNK1 (phospho-Tyr277) Rabbit Polyclonal Antibody
别名
Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8711
Human Swissprot No.
Q13470
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13470/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/83813
Mouse Swissprot No.
Q99ML2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99ML2
免疫原
Synthesized phosho peptide around human TNK1 (Tyr277)
特异性
This antibody detects endogenous levels of Human TNK1 (phospho-Tyr277)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
组织表达
Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
细胞定位
Cytoplasm . Membrane ; Peripheral membrane protein .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.,PTM:Autophosphorylated on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.,tissue specificity:Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
