产品名称
TAZ (phospho-Ser89) Rabbit Polyclonal Antibody
别名
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/25937
Human Swissprot No.
Q9GZV5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9GZV5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/97064
Mouse Swissprot No.
Q9EPK5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPK5
免疫原
Synthesized phosho peptide around human TAZ (Ser89)
特异性
This antibody detects endogenous levels of Human Mouse Rat TAZ (phospho-Ser89)
宿主
Polyclonal, Rabbit,IgG
组织表达
Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.
细胞定位
Nucleus . Cytoplasm . Cell membrane . Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity). When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity). Can be retained in the nucleus by MED15 (PubMed:18568018). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity). .
功能
domain:Binds to transcription factors via its WW domain.,domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.,function:Functions as a transcriptional coactivator.,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.,similarity:Contains 1 WW domain.,subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ.,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP.,tissue specificity:Highly expressed in kidney, heart, placenta and lung.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
