产品名称
TACC3 (phospho-Ser558) Rabbit Polyclonal Antibody
别名
Transforming acidic coiled-coil-containing protein 3 (ERIC-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10460
Human Swissprot No.
Q9Y6A5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y6A5/entry
Mouse Swissprot No.
Q9JJ11
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJ11
免疫原
Synthesized phosho peptide around human TACC3 (Ser558)
特异性
This antibody detects endogenous levels of Human TACC3 (phospho-Ser558)
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011],
组织表达
Epithelium,PCR rescued clones,Skin,
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. .
功能
function:Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer.,induction:Up-regulated in various cancer cell lines.,similarity:Belongs to the TACC family.,subunit:Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
