产品名称
TAB2 (phospho-Ser372) Rabbit Polyclonal Antibody
别名
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
基因名称
TAB2 KIAA0733 MAP3K7IP2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23118
Human Swissprot No.
Q9NYJ8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NYJ8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/68652
Mouse Swissprot No.
Q99K90
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99K90
Rat Gene Link
https://www.uniprot.org/uniprot/308267
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U303
免疫原
Synthesized phosho peptide around human TAB2 (Ser372)
特异性
This antibody detects endogenous levels of Human Mouse Rat TAB2 (phospho-Ser372)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
组织表达
Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
细胞定位
Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Toll_Like;NOD-like receptor;
功能
function:Adapter linking MAP3K7/TAK1 and TRAF6 and mediator of MAP3K7 activation in the IL1 signaling pathway.,PTM:Phosphorylated.,PTM:Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.,similarity:Contains 1 CUE domain.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Following IL1 stimulation, translocation occurs from the membrane to cytosol.,subunit:Interacts with MAP3K7 and TRAF6. Interacts with NCOR1 and HDAC3 to form a ternary complex.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
