产品名称
Stathmin (phospho-Ser16) Rabbit Polyclonal Antibody
别名
Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11075
Human Swissprot No.
Q93045
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q93045/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20257
Mouse Swissprot No.
P55821
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P55821
Rat Gene Link
https://www.uniprot.org/uniprot/84510
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P21818
免疫原
Synthesized phosho peptide around human Stathmin (Ser16)
特异性
This antibody detects endogenous levels of Human Mouse Rat Stathmin (phospho-Ser16)
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010],
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Cell projection, growth cone. Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, axon. Golgi apparatus. Endosome . Cell projection, lamellipodium. Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. .
功能
function:May play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth.,PTM:Sumoylated.,similarity:Belongs to the stathmin family.,subcellular location:Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms.,tissue specificity:Neuron specific.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.