产品名称
Stat5 (phospho-Tyr694) Rabbit Polyclonal Antibody
别名
Signal transducer and activator of transcription 5B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6777
Human Swissprot No.
P51692
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P51692/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20851
Mouse Swissprot No.
P42232
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P42232
Rat Gene Link
https://www.uniprot.org/uniprot/25126
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P52632
免疫原
Synthesized phosho peptide around human Stat5 (Tyr694)
特异性
This antibody detects endogenous levels of Human Mouse Stat5 (phospho-Tyr694)
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi
组织表达
Brain,Epithelium,Lymph,Placenta,
细胞定位
Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .
信号通路
ErbB_HER;Chemokine;Jak_STAT;Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;
功能
disease:Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.,function:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.,online information:STAT5 entry,online information:STAT5B mutation db,PTM:Tyrosine phosphorylated.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
