BD-PP1479

Scribble (phospho-Ser1220) Rabbit Polyclonal Antibody

Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)

常规抗体

SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL

Scribble (Ser1220)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

23513

https://www.uniprot.org/uniprot/23513

Q14160

https://www.uniprot.org/uniprotkb/Q14160/entry

105782

https://www.uniprot.org/uniprot/105782

Q80U72

https://www.uniprot.org/uniprotkb/Q80U72

Synthesized phosho peptide around human Scribble (Ser1220)

This antibody detects endogenous levels of Human Mouse Scribble (phospho-Ser1220)

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

179kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).

Cell membrane ; Peripheral membrane protein. Cell junction . Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity). .

similarity:Contains 4 PDZ (DHR) domains.,

现货

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.