产品名称
RPA32/RPA2 (phospho-Ser8) Rabbit Polyclonal Antibody
别名
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
基因名称
RPA2 REPA2 RPA32 RPA34
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6118
Human Swissprot No.
P15927
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P15927/entry
Mouse Swissprot No.
Q62193
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q62193
Rat Gene Link
https://www.uniprot.org/uniprot/59102
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63528
免疫原
Synthesized phosho peptide around human RPA32 and RPA2 (Ser8)
特异性
This antibody detects endogenous levels of Human RPA32 or RPA2 (phospho-Ser8)
宿主
Polyclonal, Rabbit,IgG
细胞定位
Nucleus . Nucleus, PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. .
信号通路
DNA replication;Nucleotide excision repair;Mismatch repair;Homologous recombination;
功能
function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.