产品名称
RIP3 (phospho-Ser227) Rabbit Polyclonal Antibody
别名
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11035
Human Swissprot No.
Q9Y572
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y572/entry
Mouse Swissprot No.
Q9QZL0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZL0
Rat Gene Link
https://www.uniprot.org/uniprot/246240
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z2P5
免疫原
Synthesized phosho peptide around human RIP3 (Ser227)
特异性
This antibody detects endogenous levels of Human RIP3 (phospho-Ser227)
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. ; [Isoform 3]: Expression is significantly increased in colon and lung cancers.
细胞定位
Cytoplasm, cytosol . Nucleus . Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. .
信号通路
Cytosolic DNA-sensing pathway;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Promotes apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex.,tissue specificity:Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
