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Rad18 (phospho-Ser403) Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PP1458
产品名称
Rad18 (phospho-Ser403) Rabbit Polyclonal Antibody
别名
E3 ubiquitin-protein ligase RAD18 (EC 6.3.2.-) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73)
类别
常规抗体
基因名称
RAD18 RNF73
蛋白名称
Rad18 (Ser403)
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
56852
Human Gene Link
https://www.uniprot.org/uniprot/56852
Human Swissprot No.
Q9NS91
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NS91/entry
Mouse Gene ID
58186
Mouse Gene Link
https://www.uniprot.org/uniprot/58186
Mouse Swissprot No.
Q9QXK2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QXK2
免疫原
Synthesized phosho peptide around human Rad18 (Ser403)
特异性
This antibody detects endogenous levels of Human Rad18 (phospho-Ser403)
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
预测分子量
56kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008],
组织表达
Epithelium,Liver,Placenta,
细胞定位
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). .
功能
function:E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the RAD18 family.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SAP domain.,subunit:Interacts with UBE2A and UBE2B. Interacts with SHPRH.,
期货
现货
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

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