产品名称
PPIG (phospho-Ser376) Rabbit Polyclonal Antibody
别名
Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9360
Human Swissprot No.
Q13427
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13427/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/228005
Mouse Swissprot No.
A2AR02
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2AR02
Rat Gene Link
https://www.uniprot.org/uniprot/83624
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O55035
免疫原
Synthesized phosho peptide around human PPIG (Ser376)
特异性
This antibody detects endogenous levels of Human Mouse Rat PPIG (phospho-Ser376)
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
细胞定位
Nucleus matrix . Nucleus speckle . Colocalizes with RNA splicing factors at nuclear speckles. .
功能
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,domain:The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.,enzyme regulation:Cyclosporin A (CsA)-sensitive.,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Colocalizes with RNA splicing factors at nuclear speckles.,subunit:Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
