产品名称
PLCγ2 (phospho-Tyr759) Rabbit Polyclonal Antibody
别名
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5336
Human Swissprot No.
P16885
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P16885/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/234779
Mouse Swissprot No.
Q8CIH5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CIH5
Rat Gene Link
https://www.uniprot.org/uniprot/29337
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P24135
免疫原
Synthesized phosho peptide around human PLCγ2 (Tyr759)
特异性
This antibody detects endogenous levels of Human Mouse PLCγ2 (phospho-Tyr759)
稀释度
WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],
组织表达
Lymph,Lymphoblast,Spleen,T-cell,
细胞定位
intracellular,cytosol,plasma membrane,extracellular exosome,
信号通路
Inositol phosphate metabolism;ErbB_HER;Calcium;Phosphatidylinositol signaling system;VEGF;Natural killer cell mediated cytotoxicity;B_Cell_Antigen;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin;Vibrio chol
功能
catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
