产品名称
PI3 Kinase Class III (phospho-Ser249) Rabbit Polyclonal Antibody
别名
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)
蛋白名称
PI3 Kinase Class III (Ser249)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5289
Human Swissprot No.
Q8NEB9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NEB9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/225326
Mouse Swissprot No.
Q6PF93
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PF93
Rat Gene Link
https://www.uniprot.org/uniprot/65052
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88763
免疫原
Synthesized phosho peptide around human PI3 Kinase Class III (Ser249)
特异性
This antibody detects endogenous levels of Human PI3 Kinase Class III (phospho-Ser249)
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
组织表达
Ubiquitously expressed, with a highest expression in skeletal muscle.
细胞定位
Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). .
信号通路
Inositol phosphate metabolism;Phosphatidylinositol signaling system;Regulation of autophagy;
功能
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.,cofactor:Manganese.,function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4.,tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
