产品名称
p90RSK (phospho-Thr359/Ser363) Rabbit Polyclonal Antibody
别名
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
基因名称
RPS6KA1 MAPKAPK1A RSK1
蛋白名称
p90RSK (Thr359/Ser363)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6195
Human Swissprot No.
Q15418
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15418/entry
Mouse Swissprot No.
P18653
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P18653
Rat Gene Link
https://www.uniprot.org/uniprot/81771
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63531
免疫原
Synthesized phosho peptide around human p90RSK (Thr359 and Ser363)
特异性
This antibody detects endogenous levels of Human Mouse Rat p90RSK (phospho-Thr359 or Ser363)
宿主
Polyclonal, Rabbit,IgG
背景介绍
ribosomal protein S6 kinase A1(RPS6KA1) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
信号通路
Regulates Angiogenesis; Insulin Receptor; B Cell Receptor; AMPK
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-380, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
