产品名称
p70 S6 Kinase (phospho-Thr389) Rabbit Polyclonal Antibody
别名
Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)
基因名称
RPS6KB1 STK14A P70S6K
蛋白名称
Ribosomal protein S6 kinase beta-1，p70 S6 Kinase (Thr389)
反应种属
Human,Mouse,Rat,Bovine
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6198
Human Swissprot No.
P23443
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23443/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72508
Mouse Swissprot No.
Q8BSK8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BSK8
Rat Gene Link
https://www.uniprot.org/uniprot/83840
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P67999
免疫原
Synthesized phosho peptide around human p70 S6 Kinase (Thr389)
特异性
This antibody detects endogenous levels of Human Mouse Rat p70 S6 Kinase (phospho-Thr389)
宿主
Polyclonal, Rabbit,IgG
背景介绍
ribosomal protein S6 kinase B1(RPS6KB1) Homo sapiens This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013],
细胞定位
Cell junction, synapse, synaptosome . Mitochondrion outer membrane. Mitochondrion. Colocalizes with URI1 at mitochondrion.; [Isoform Alpha I]: Nucleus. Cytoplasm.; [Isoform Alpha II]: Cytoplasm.
信号通路
Regulates Angiogenesis; Insulin Receptor; ErbB/HER; mTOR; B Cell Receptor; PI3K/Akt; PI3K/Akt; AMPK
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activation by serine/threonine phosphorylation and protein kinase C, inactivated by type 2A phosphatase.,function:Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1R9A/neurabin-1.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
