BD-PP1407

Mre11 (phospho-Ser676) Rabbit Polyclonal Antibody

Double-strand break repair protein MRE11A (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)

常规抗体

MRE11A HNGS1 MRE11

Mre11 (Ser676)

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

4361

https://www.uniprot.org/uniprot/4361

P49959

https://www.uniprot.org/uniprotkb/P49959/entry

17535

https://www.uniprot.org/uniprot/17535

Q61216

https://www.uniprot.org/uniprotkb/Q61216

64046

https://www.uniprot.org/uniprot/64046

Q9JIM0

https://www.uniprot.org/uniprotkb/Q9JIM0

Synthesized phosho peptide around human Mre11 (Ser676)

This antibody detects endogenous levels of Human Mre11 (phospho-Ser676)

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

80kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Bladder,Brain,Epithelium,Lung,

Nucleus . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents. .

Homologous recombination;Non-homologous end-joining;

cofactor:Manganese.,disease:Defects in MRE11A are a cause of ataxia telangiectasia-like disorder (ATLD) [MIM:604391]. ATLD is a disease with the same clinical feature than ataxia-telangiectasia but with a somewhat milder clinical course.,disease:Defects in MRE11A may be a cause of breast cancer.,function:Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.,miscellaneous:In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.,online information:MRE11A mutation db,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MRE11/RAD32 family.,subcellular location:Localizes to discrete nuclear foci after treatment with genotoxic agents.,subunit:Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN (By similarity). Interacts with DCLRE1C/Artemis.,

现货

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.