产品名称
MKK7 (phospho-Ser271/Thr275) Rabbit Polyclonal Antibody
别名
Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
基因名称
MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4
蛋白名称
MKK7 (Ser271/Thr275)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5609
Human Swissprot No.
O14733
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14733/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/26400
Mouse Swissprot No.
Q8CE90
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CE90
Rat Gene Link
https://www.uniprot.org/uniprot/363855
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4KSH7
免疫原
Synthesized phosho peptide around human MKK7 (Ser271 and Thr275)
特异性
This antibody detects endogenous levels of Human MKK7 (phospho-Ser271 or Thr275)
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
组织表达
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
细胞定位
Nucleus. Cytoplasm .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Toll_Like;T_Cell_Receptor;Fc epsilon RI;Neurotrophin;GnRH;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.,function:Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.,PTM:Activated by phosphorylation on Ser/Thr.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
