产品名称
M-CSF Receptor (phospho-Tyr923) Rabbit Polyclonal Antibody
别名
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
蛋白名称
M-CSF Receptor (Tyr923)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1436
Human Swissprot No.
P07333
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P07333/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12978
Mouse Swissprot No.
P09581
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P09581
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q00495
免疫原
Synthesized phosho peptide around human M-CSF Receptor (Tyr923)
特异性
This antibody detects endogenous levels of Human M-CSF Receptor (phospho-Tyr923)
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
组织表达
Expressed in bone marrow and in differentiated blood mononuclear cells.
细胞定位
Cell membrane; Single-pass type I membrane protein.
信号通路
Cytokine-cytokine receptor interaction;Endocytosis;Hematopoietic cell lineage;Pathways in cancer;
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with INPPL1/SHIP2 and THOC5.,tissue specificity:Expressed in bone marrow and in differentiated blood mononuclear cells.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
