产品名称
MARCKS (phospho-Ser167/170) Rabbit Polyclonal Antibody
别名
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4082
Human Swissprot No.
P29966
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P29966/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17118
Mouse Swissprot No.
P26645
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P26645
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P30009
免疫原
Synthesized phosho peptide around human MARCKS (Ser167 and 170)
特异性
This antibody detects endogenous levels of Human Mouse Rat MARCKS (phospho-Ser167 or 170)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008],
组织表达
Blood,Brain,Epithelium,Muscle,Skin,
细胞定位
Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor .
信号通路
Fc gamma R-mediated phagocytosis;
功能
function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.,similarity:Belongs to the MARCKS family.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
