产品名称
LDHA (phospho-Tyr10) Rabbit Polyclonal Antibody
别名
L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3939
Human Swissprot No.
P00338
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P00338/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16828
Mouse Swissprot No.
P06151
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P06151
Rat Gene Link
https://www.uniprot.org/uniprot/24533
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P04642
免疫原
Synthesized phosho peptide around human LDHA (Tyr10)
特异性
This antibody detects endogenous levels of Human Mouse Rat LDHA (phospho-Tyr10)
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],
组织表达
Predominantly expressed in anaerobic tissues such as skeletal muscle and liver.
信号通路
Glycolysis / Gluconeogenesis;Cysteine and methionine metabolism;Pyruvate metabolism;Propanoate metabolism;
功能
catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
