产品名称
GTSE1 Rabbit Polyclonal Antibody
蛋白名称
G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NYZ3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NYZ3/entry
Mouse Swissprot No.
Q8R080
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R080
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
GTSE1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008],
组织表达
Brain,Epithelium,Liver,Muscle,Placenta,
细胞定位
Cytoplasm, cytoskeleton. Associated with microtubules.
功能
developmental stage:Expressed in G2/M phase. Not detected in quiescent cells.,function:May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.,PTM:Phosphorylated in mitosis.,subcellular location:Associated with microtubules.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
