产品名称
IKKε (phospho-Ser172) Rabbit Polyclonal Antibody
别名
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
基因名称
IKBKE IKKE IKKI KIAA0151
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9641
Human Swissprot No.
Q14164
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14164/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56489
Mouse Swissprot No.
Q9R0T8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R0T8
免疫原
Synthesized phosho peptide around human IKKε (Ser172)
特异性
This antibody detects endogenous levels of Human IKKε (phospho-Ser172)
宿主
Polyclonal, Rabbit,IgG
背景介绍
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009],
组织表达
Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
细胞定位
Cytoplasm . Nucleus. Nucleus, PML body . Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669). Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218). .
信号通路
Toll_Like;RIG-I-like receptor;Cytosolic DNA-sensing pathway;
功能
catalytic activity:ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].,function:Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE.,tissue specificity:Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
