产品名称
GRB10 (phospho-Ser476) Rabbit Polyclonal Antibody
别名
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
基因名称
GRB10 GRBIR KIAA0207
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2887
Human Swissprot No.
Q13322
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13322/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14783
Mouse Swissprot No.
Q60760
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60760
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P0CE43
免疫原
Synthesized phosho peptide around human GRB10 (Ser476)
特异性
This antibody detects endogenous levels of Human Mouse GRB10 (phospho-Ser476)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010],
组织表达
Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.
细胞定位
Cytoplasm . When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). .
信号通路
Stem cell pathway; Insulin Receptor
功能
alternative products:Additional isoforms seem to exist,function:Plays a functional role in insulin and IGF-I signaling. May serve to positively link the insulin and IGF-I receptors to an uncharacterized mitogenic signaling pathway. Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds activated platelet-derived growth factor receptor and epidermal growth factor receptor.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15.,tissue specificity:Highly expressed in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
