产品名称
FRS2-α (phospho-Tyr196) Rabbit Polyclonal Antibody
别名
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10818
Human Swissprot No.
Q8WU20
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WU20/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/327826
Mouse Swissprot No.
Q8C180
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C180
免疫原
Synthesized phosho peptide around human FRS2-α (Tyr196)
特异性
This antibody detects endogenous levels of Human Mouse FRS2-α (phospho-Tyr196)
宿主
Polyclonal, Rabbit,IgG
组织表达
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
细胞定位
Endomembrane system. Cytoplasmic, membrane-bound.
功能
function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
