产品名称
DR6 (phospho-Ser562) Rabbit Polyclonal Antibody
别名
Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
基因名称
TNFRSF21 DR6 UNQ437/PRO868
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27242
Human Swissprot No.
O75509
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75509/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/94185
Mouse Swissprot No.
Q9EPU5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPU5
免疫原
Synthesized phosho peptide around human DR6 (Ser562)
特异性
This antibody detects endogenous levels of Human Mouse Rat DR6 (phospho-Ser562)
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013],
组织表达
Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
信号通路
Cytokine-cytokine receptor interaction;
功能
caution:It is uncertain whether Met-1 or Met-25 is the initiator.,function:May activate NF-kappa-B and JNK and promote apoptosis.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Associates with TRADD.,tissue specificity:Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
