产品名称
DARPP-32 (phospho-Ser97) Rabbit Polyclonal Antibody
别名
Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84152
Human Swissprot No.
Q9UD71
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UD71/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19049
Mouse Swissprot No.
Q60829
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60829
Rat Gene Link
https://www.uniprot.org/uniprot/360616
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6J4I0
免疫原
Synthesized phosho peptide around human DARPP-32 (Ser97)
特异性
This antibody detects endogenous levels of Human Mouse Rat DARPP-32 (phospho-Ser97)
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
组织表达
Adipose tissue,Brain,Cerebellum,Colon,Ovary,
功能
function:Inhibitor of protein-phosphatase 1.,PTM:Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.,PTM:Phosphorylation of Thr-34 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
