产品名称
Cyclin E1 (phospho-Thr62) Rabbit Polyclonal Antibody
别名
G1/S-specific cyclin-E1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/898
Human Swissprot No.
P24864
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P24864/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12447
Mouse Swissprot No.
Q61457
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61457
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P39949
免疫原
Synthesized phosho peptide around human Cyclin E1 (Thr62)
特异性
This antibody detects endogenous levels of Human Cyclin E1 (phospho-Thr62)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in
组织表达
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;p53;Pathways in cancer;Prostate cancer;Small cell lung cancer;
功能
function:Essential for the control of the cell cycle at the G1/S (start) transition.,PTM:Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cyclin family. Cyclin E subfamily.,subunit:Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1.,tissue specificity:Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
