产品名称
CARD11 (phospho-Ser652) Rabbit Polyclonal Antibody
别名
Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84433
Human Swissprot No.
Q9BXL7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BXL7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/108723
Mouse Swissprot No.
Q8CIS0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CIS0
免疫原
Synthesized phosho peptide around human CARD11 (Ser652)
特异性
This antibody detects endogenous levels of Human Mouse Rat CARD11 (phospho-Ser652)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],
组织表达
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.
细胞定位
Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .
信号通路
T_Cell_Receptor;B_Cell_Antigen;
功能
caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.,function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.,similarity:Contains 1 CARD domain.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:CARD11 and BCL10 bind to each other by CARD-CARD interaction.,tissue specificity:Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
