产品名称
CALY Rabbit Polyclonal Antibody
蛋白名称
Neuron-specific vesicular protein calcyon
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NYX4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NYX4/entry
Mouse Swissprot No.
Q9DCA7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DCA7
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P58821
免疫原
Synthesized peptide derived from human protein . at AA range: 1-80
特异性
CALY Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
calcyon neuron specific vesicular protein(CALY) Homo sapiens The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.
细胞定位
Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
功能
caution:Was originally (PubMed:10698743) thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.,function:Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.,PTM:Glycosylated.,similarity:Belongs to the NSG family.,subunit:Interacts with CLTA.,tissue specificity:Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
