产品名称
Axl (phospho-Tyr702) Rabbit Polyclonal Antibody
别名
AXL; UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/558
Human Swissprot No.
P30530
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30530/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/26362
Mouse Swissprot No.
Q00993
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q00993
免疫原
Synthesized phosho peptide around human Axl (Tyr702)
特异性
This antibody detects endogenous levels of Human Axl (phospho-Tyr702)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Although authors have considered STK6 and STK15 as two different proteins, it is clear that they are the same protein.,disease:Defects in AURKA are responsible for numerical centrosome aberrations including aneuploidy.,function:May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. May be involved in microtubule formation and/or stabilization. Phosphorylates ARHGEF2 and BORA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.,subunit:Interacts with TACC1 and CPEB1. Interacts with its substrates BORA and ARHGEF2.,tissue specificity:Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
