产品名称
DCNL3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/123879
Human Swissprot No.
Q8IWE4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IWE4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/233805
Mouse Swissprot No.
Q8K0V2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K0V2
Rat Gene Link
https://www.uniprot.org/uniprot/309035
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4V8B2
免疫原
Synthesized peptide derived from human DCNL3 AA range: 205-255
特异性
This antibody detects endogenous levels of DCNL3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416). Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts (PubMed:18823379). Palmitoylation stabilizes DCUN1D3 at the cell membrane (PubMed:19617556).
细胞定位
Cell membrane . Cytoplasm . Nucleus . Cytoplasm, perinuclear region . After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). .
功能
similarity:Contains 1 DCUN1 domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
