产品名称
MTMRC Rabbit Polyclonal Antibody
基因名称
MTMR12 KIAA1682 PIP3AP
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54545
Human Swissprot No.
Q9C0I1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9C0I1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/268783
Mouse Swissprot No.
Q80TA6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80TA6
Rat Gene Link
https://www.uniprot.org/uniprot/310155
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5FVM6
免疫原
Synthesized peptide derived from human MTMRC AA range: 523-573
特异性
This antibody detects endogenous levels of MTMRC at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
组织表达
Expressed in skeletal muscles (at protein level) (PubMed:23818870). Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung (PubMed:11504939).
细胞定位
Cytoplasm . Sarcoplasmic reticulum . Cytoplasm, myofibril, sarcomere . Localizes to punctate vesicles when associated with MTM1 (PubMed:12847286). Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna (By similarity). In skeletal muscles, co-localizes with MTM1 in the sarcomere (By similarity). Partially localizes to the sarcoplasmic reticulum in skeletal muscles (By similarity). .
功能
caution:Lacks the phosphocysteine intermediate Cys active site in position 391 that is replaced by a Glu residue, preventing the hydrolase activity.,function:Inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.,miscellaneous:Catalytically inactive phosphatase.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.,similarity:Contains 1 myotubularin phosphatase domain.,subcellular location:Localizes to punctate vesicles when associated with MTM1.,subunit:Interacts with myotubularin MTM1 and myotubularin-related MTMR2.,tissue specificity:Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
