产品名称
STXB2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6813
Human Swissprot No.
Q15833
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15833/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20911
Mouse Swissprot No.
Q64324
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q64324
Rat Gene Link
https://www.uniprot.org/uniprot/81804
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62753
免疫原
Synthesized peptide derived from human STXB2 AA range: 392-442
特异性
This antibody detects endogenous levels of STXB2 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013],
组织表达
Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
细胞定位
cytosol,plasma membrane,integral component of membrane,apical plasma membrane,SNARE complex,specific granule,azurophil granule,zymogen granule membrane,cytolytic granule,extracellular exosome,tertiary granule,
功能
function:Involved in the protein trafficking from the Golgi apparatus to the plasma membrane.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subunit:Binds syntaxins 1A, 2, 3 but not 4.,tissue specificity:Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
