产品名称
EVI5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7813
Human Swissprot No.
O60447
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60447/entry
Mouse Swissprot No.
P97366
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97366
免疫原
Synthesized peptide derived from human EVI5 AA range: 1-51
特异性
This antibody detects endogenous levels of EVI5 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.
细胞定位
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.
功能
disease:A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated.,function:Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.,induction:Down-regulated during mitosis through proteasomal degradation.,miscellaneous:Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.,PTM:Probably phosphorylated by PLK1; may be required for degradation during mitosis.,PTM:Ubiquitinated. Degradation during prophase is ubiquitin-dependent.,similarity:Contains 1 Rab-GAP TBC domain.,subcellular location:Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.,subunit:Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP.,tissue specificity:Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
