产品名称
PRGC2 Rabbit Polyclonal Antibody
基因名称
PPARGC1B PERC PGC1 PGC1B PPARGC1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/133522
Human Swissprot No.
Q86YN6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86YN6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/170826
Mouse Swissprot No.
Q8VHJ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VHJ7
Rat Gene Link
https://www.uniprot.org/uniprot/291567
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q811R2
免疫原
Synthesized peptide derived from human PRGC2 AA range: 829-879
特异性
This antibody detects endogenous levels of PRGC2 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
组织表达
Ubiquitous with higher expression in heart, brain and skeletal muscle.
功能
domain:Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.,function:Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.,induction:Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics.,polymorphism:Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA (By similarity). Interacts with estrogen receptor alpha/ESR1.,tissue specificity:Ubiquitous with higher expression in heart, brain and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
