产品名称
FAN1 Rabbit Polyclonal Antibody
基因名称
FAN1 KIAA1018 MTMR15
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/22909
Human Swissprot No.
Q9Y2M0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y2M0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/330554
Mouse Swissprot No.
Q69ZT1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q69ZT1
免疫原
Synthesized peptide derived from human FAN1 AA range: 801-851
特异性
This antibody detects endogenous levels of FAN1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016],
细胞定位
Nucleus . Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ4-type zinc finger (PubMed:20935496). .
功能
similarity:Belongs to the MTMR15 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
