产品名称
STABP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10617
Human Swissprot No.
O95630
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95630/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/70527
Mouse Swissprot No.
Q9CQ26
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQ26
Rat Gene Link
https://www.uniprot.org/uniprot/171565
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R424
免疫原
Synthesized peptide derived from human STABP AA range: 109-159
特异性
This antibody detects endogenous levels of STABP at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed.
细胞定位
Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,cofactor:Binds 2 zinc ion per subunit.,domain:The JAMM motif is essential for the protease activity.,enzyme regulation:Inhibited by N-ethylmaleimide.,function:Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.,miscellaneous:X-ray crystallography studies of STAMBPL1, another member of the peptidase M67C family, has shown that Glu-280 binds zinc indirectly via a water molecule. Nevertheless, this residue is essential for catalytic activity.,PTM:Phosphorylated after BMP type I receptor activation.,similarity:Belongs to the peptidase M67C family.,similarity:Contains 1 MPN (JAB/Mov34) domain.,subunit:Interacts with STAM1. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
