产品名称
CP51A Rabbit Polyclonal Antibody
蛋白名称
Lanosterol 14-alpha demethylase (LDM) (EC 1.14.13.70) (CYPLI) (Cytochrome P450 51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q16850
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16850/entry
Mouse Swissprot No.
Q8K0C4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K0C4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q64654
免疫原
Synthesized peptide derived from human protein . at AA range: 210-290
特异性
CP51A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
cytochrome P450 family 51 subfamily A member 1(CYP51A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
组织表达
Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .
信号通路
Steroid biosynthesis;
功能
catalytic activity:Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O.,cofactor:Heme group.,function:Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.,pathway:Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostrate, liver, kidney and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
