产品名称
PIM3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/415116
Human Swissprot No.
Q86V86
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86V86/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/223775
Mouse Swissprot No.
P58750
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P58750
Rat Gene Link
https://www.uniprot.org/uniprot/64534
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O70444
免疫原
Synthesized peptide derived from human PIM3 AA range: 102-152
特异性
This antibody detects endogenous levels of PIM3 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012],
组织表达
Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May be involved in cell cycle progression and anti-apoptosis process. Implicated in proliferation of human hepatoma cell lines.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Widely expressed. No expression in colon, thymus, and small intestine. Expressed in human hepatoma cell lines but not in normal liver tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
