产品名称
ARY2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10
Human Swissprot No.
P11245
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P11245/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17961
Mouse Swissprot No.
P50295
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P50295
Rat Gene Link
https://www.uniprot.org/uniprot/116632
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P50298
免疫原
Synthesized peptide derived from human ARY2 AA range: 80-130
特异性
This antibody detects endogenous levels of ARY2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008],
功能
catalytic activity:Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.,disease:Genetic variations in NAT2 determine N-acetylation polymorphism by a low or high NAT activity in the liver [MIM:243400]. It has been implicated in the action and toxicity of amine-containing drugs, and in the susceptibility to bladder cancer and systemic lupus erythematosus. This isozyme is responsible for this polymorphism.,function:Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.,online information:NAT alleles,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the arylamine N-acetyltransferase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
