产品名称
LEO1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/123169
Human Swissprot No.
Q8WVC0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WVC0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/235497
Mouse Swissprot No.
Q5XJE5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XJE5
Rat Gene Link
https://www.uniprot.org/uniprot/300837
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q641X2
免疫原
Synthesized peptide derived from human LEO1 AA range: 159-209
特异性
This antibody detects endogenous levels of LEO1 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008],
组织表达
Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver.
功能
function:The PAF1 complex is a multifunctional complex. The PAF1 complex interacts with POLR2A. May be involved in both initiation and elongation, histone methylation and RNA processing. Overexpression of LEO1 induces cell growth arrest and premature senescence of fibroblasts.,similarity:Belongs to the LEO1 family.,subunit:Component of the PAF1 complex, which consists of at least of CDC73, PAF1, LEO1 and CTR9. Interacts with CDC73.,tissue specificity:Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
