产品名称
STX7 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8417
Human Swissprot No.
O15400
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15400/entry
Mouse Swissprot No.
O70439
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70439
Rat Gene Link
https://www.uniprot.org/uniprot/100910446
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O70257
免疫原
Synthesized peptide derived from human STX7 AA range: 42-92
特异性
This antibody detects endogenous levels of STX7 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016],
组织表达
Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.
细胞定位
Early endosome membrane ; Single-pass type IV membrane protein .
功能
function:May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.,similarity:Belongs to the syntaxin family.,similarity:Contains 1 t-SNARE coiled-coil homology domain.,subunit:Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Interacts with VPS33A. Found in a complex with VAMP8 and VTI1B in the liver. Part of the SNARE core complex containing VAMP8, STX8 and VTI1B (By similarity). Interacts with VPS11, VPS16 and VPS18.,tissue specificity:Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
